The extracellular matrix (ECM) is the protein rich system that induces cellular behavior in response to microenvironmental cues. In disease models of sepsis, interstitial lung disease, and arthritis, we understand that a provisional extracellular matrix is created in the affected tissue, altering matrix driven signals and subsequent cell activity in response to the newly modified microenvironment. Through the development of polymer based ECM mimetics, we can dissect the role of individual bioactive domains within each ECM protein, to elucidate the changes in cellular behavior that can be attributed to cellECM binding interactions. Further, we can identify individual functional domains within proteins that will contribute to control of leukocyte adhesion, migration, oxidant generation, differentiation and survival in inflammatory disorders. Our findings can be translated directly to therapeutic treatments for wound healing, chronic infection, and lymphomas
Outside-In Signaling: Immune regulation by biomaterial mimetics of the extravascular spac
Speaker:
Assistant Professor Anjelica Gonzalez
Department of Biomedical Engineering
School of Engineering & Applied Science, Yale University
Seminar Date:
Friday, November 4, 2011 - 12:00pm
Location:
BECTON SEMINAR ROOM
Prospect Street
New Haven, CT
Host:
Paul Fleury
Seminar Announcement Brochure: