Bulk metallic glasses are a unique class of amorphous materials with corrosion resistance and high yield strength that can be processed like plastics to create a range of complex micro and nanotopographical features. By harnessing the range of surface modifications of platinum-based BMGs, our lab studies how topography and composition can affect cell function in vitro and in vivo to inform the use of BMGs as biomedical implants with orthopedic, cardiovascular, monitoring applications and more. The highly tunable nature of BMGs enables the creation of a wide range of surface topography that can be reproducibly and systematically studied with thorough investigation of how surface modifications drive cellular changes leading to the development of better performing, bioactive implants.